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In vitro method for 3D morphometry of human articular cartilage chondrons based on micro-computed tomography.

I Kestilä | J Thevenot | M A Finnilä | S S Karhula | I Hadjab | S Kauppinen | M Garon | E Quenneville | M Haapea | L Rieppo | K P Pritzker | M D Buschmann | H J Nieminen | S Saarakkala
Osteoarthritis and cartilage | 2018

The aims of this study were: to 1) develop a novel sample processing protocol to visualize human articular cartilage (AC) chondrons using micro-computed tomography (μCT), 2) develop and validate an algorithm to quantify the chondron morphology in 3D, and 3) compare the differences in chondron morphology between intact and osteoarthritic AC.

Pubmed ID: 29802974

Research resources used in this publication

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Associated grants

  • Agency: European Research Council, International
    Id: 336267

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Mimics (tool)

RRID:SCR_012153

Software for medical image processing. Use Mimics for the segmentation of 3D medical images (coming from CT, MRI, microCT, CBCT, Ultrasound, Confocal Microscopy) and the result will be highly accurate 3D models of your patient''s anatomy. You can then use these patient-specific models for a variety of engineering applications directly in Mimics or 3-matic, or export the 3D models and anatomical landmark points to 3rd party software, like statistical, CAD, or FEA packages.

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