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Publication

In vivo evaluation of two tissue transglutaminase PET tracers in an orthotopic tumour xenograft model.

Berend van der Wildt | Micha M M Wilhelmus | Wissam Beaino | Esther J M Kooijman | Robert C Schuit | John G J M Bol | John J P Breve | Ralf Pasternack | Adriaan A Lammertsma | Albert D Windhorst | Benjamin Drukarch
EJNMMI research | 2018

The protein cross-linking enzyme tissue transglutaminase (TG2; EC 2.3.2.13) is associated with the pathogenesis of various diseases, including cancer. Recently, the synthesis and initial evaluation of two high-potential radiolabelled irreversible TG2 inhibitors were reported by us. In the present study, these two compounds were evaluated further in a breast cancer (MDA-MB-231) tumour xenograft model for imaging active tissue transglutaminase in vivo.

Pubmed ID: 29802556

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GE Healthcare (tool)

RRID:SCR_000004

A commercial antibody supplier and provider of various services.

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MDA-MB-231 (tool)

RRID:CVCL_0062

Cell line MDA-MB-231 is a Cancer cell line with a species of origin Homo sapiens (Human)

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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