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Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality.

Jared A Greenberg | Cara L Hrusch | Mohammad R Jaffery | Michael Z David | Robert S Daum | Jesse B Hall | John P Kress | Anne I Sperling | Philip A Verhoef
Critical care (London, England) | 2018

The dysregulated host immune response that defines sepsis varies as a function of both the immune status of the host and the distinct nature of the pathogen. The degree to which immunocompromising comorbidities or immunosuppressive medications affect the immune response to infection is poorly understood because these patients are often excluded from studies about septic immunity. The objectives of this study were to determine the immune response to a single pathogen (Staphylococcus aureus) among a diverse case mix of patients and to determine whether comorbidities affect immune and clinical outcomes.

Pubmed ID: 29695270

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Associated grants

  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR000430
  • Agency: NHLBI NIH HHS, United States
    Id: K08 HL132109
  • Agency: NHLBI NIH HHS, United States
    Id: T32 HL007605

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FlowJo (tool)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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Stata (tool)

RRID:SCR_012763

A Software resource for statistical analysis and presentation of graphics.

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