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Gliomas comprise heterogeneous malignant glial and stromal cells. While blood vessel co-option is a potential mechanism to escape anti-angiogenic therapy, the relevance of glial phenotype in this process is unclear. We show that Olig2+ oligodendrocyte precursor-like glioma cells invade by single-cell vessel co-option and preserve the blood-brain barrier (BBB). Conversely, Olig2-negative glioma cells form dense perivascular collections and promote angiogenesis and BBB breakdown, leading to innate immune cell activation. Experimentally, Olig2 promotes Wnt7b expression, a finding that correlates in human glioma profiling. Targeted Wnt7a/7b deletion or pharmacologic Wnt inhibition blocks Olig2+ glioma single-cell vessel co-option and enhances responses to temozolomide. Finally, Olig2 and Wnt7 become upregulated after anti-VEGF treatment in preclinical models and patients. Thus, glial-encoded pathways regulate distinct glioma-vascular microenvironmental interactions.
Pubmed ID: 29681511
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This monoclonal targets CD140a
View all literature mentionsThis monoclonal targets Olig2
View all literature mentionsThis polyclonal targets Von Willebrand Factor
View all literature mentionsThis monoclonal targets Active-beta-Catenin
View all literature mentionsThis polyclonal targets Wnt7b antibody
View all literature mentionsThis monoclonal targets Nkx2.2 transcription factor
View all literature mentionsThis polyclonal targets N-terminus of mouse Olig2
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View all literature mentionsThis polyclonal targets Fibrinogen antibody
View all literature mentionsThis polyclonal targets Human CD31, prediluted
View all literature mentionsThis monoclonal targets Vascular Endothelial Growth Factor (VEGF)
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View all literature mentionsThis polyclonal targets Collagen Type IV
View all literature mentionsThis monoclonal targets SGCG
View all literature mentionsThis polyclonal targets GFAP
View all literature mentionsThis monoclonal targets beta-Tubulin
View all literature mentionsThis polyclonal targets Iba1
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets IDH1 R132H
View all literature mentionsThis polyclonal targets H3K27ac
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis monoclonal targets GAPDH antibody [6C5]
View all literature mentionsThis monoclonal targets beta-Actin
View all literature mentionsThis monoclonal targets LEF1 (C12A5) Rabbit mAb
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View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
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View all literature mentionsCell line U-87MG ATCC is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsMus musculus with name FVB/NCrl from IMSR.
View all literature mentionsMus musculus with name IcrTac:ICR-Prkdcscid from IMSR.
View all literature mentionsMus musculus with name B6;129X1-Wnt7btm2Amc/J from IMSR.
View all literature mentionsMus musculus with name B6;129S1-Wnt7atm1Amc/J from IMSR.
View all literature mentionsMus musculus with name NOD.Cg-Prkdcscid/J from IMSR.
View all literature mentionsMetadatabase manually curated that provides web accessible tools related to genomics, transcriptomics, proteomics and metabolomics. Used as informative directory for multi-omic data analysis.
View all literature mentionsMus musculus with name STOCK Olig2tm2(TVA.cre)Rth/J from IMSR.
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