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Publication

Radiosensitization of clioquinol and zinc in human cancer cell lines.

Shan Lu | Yuan Ke | Chaoyan Wu | Yahua Zhong | Conghua Xie | Yunfeng Zhou | Fuxiang Zhou | Haijun Yu
BMC cancer | 2018

We previously reported that clioquinol acts as a zinc ionophore and inhibits the NF-κB signalling pathway. Other research has demonstrated that zinc deficiency plays a vital role in the occurrence and development of some solid tumours, and intracellular zinc supplementation may reverse this process and enhance the tumour sensitivity to anticancer treatment. Thus, we investigated the radiosensitization effects of clioquinol combined with zinc on HeLa and MCF-7 cells in vitro.

Pubmed ID: 29678153

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Associated grants

  • Agency: the National Natural Science Foundation of China, International
    Id: NO.81201755

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

MCF-7 (tool)

RRID:CVCL_0031

Cell line MCF-7 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

HeLa (tool)

RRID:CVCL_0030

Cell line HeLa is a Cancer cell line with a species of origin Homo sapiens

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