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Publication

Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats.

Allan K Alencar | Fábio I Carvalho | Ananssa M Silva | Sabrina T Martinez | Jorge A Calasans-Maia | Carlos M Fraga | Eliezer J Barreiro | Gisele Zapata-Sudo | Roberto T Sudo
PloS one | 2018

Pulmonary hypertension (PH) is characterized by enhanced pulmonary vascular resistance, which causes right ventricle (RV) pressure overload and results in right sided heart failure and death. This work investigated the effectiveness of a combined therapy with PDE5 inhibitor (PDE5i) and a new adenosine A2A receptor (A2AR) agonist in mitigating monocrotaline (MCT) induced PH in rats.

Pubmed ID: 29677206

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WI (tool)

RRID:RGD_13508588

Rattus norvegicus with name WI from RGD.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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