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Glycation of high-density lipoprotein triggers oxidative stress and promotes the proliferation and migration of vascular smooth muscle cells.

Qian Du | Ming-Ming Qian | Pin-Li Liu | Le Zhang | Yan Wang | Dong-Hui Liu
Journal of geriatric cardiology : JGC | 2017

In type 2 diabetes mellitus (T2DM), high-density lipoprotein (HDL) impairs its anti-atherogenic properties and even develops to a pro-inflammatory and pro-atherogenic phenotype because of abnormal compositions and modifications. In this study, we examined the effects and the related mechanisms of glycation of HDL on the proliferation and migration of vascular smooth muscle cells (VSMCs).

Pubmed ID: 28868076

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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