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AT1-receptor response to non-saturating Ang-II concentrations is amplified by calcium channel blockers.

Kristoffer Bernhem | Kalaiselvan Krishnan | Alexander Bondar | Hjalmar Brismar | Anita Aperia | Lena Scott
BMC cardiovascular disorders | 2017

Blockers of angiotensin II type 1 receptor (AT1R) and the voltage gated calcium channel 1.2 (CaV1.2) are commonly used for treatment of hypertension. Yet there is little information about the effect of physiological concentrations of angiotensin II (AngII) on AT1R signaling and whether there is a reciprocal regulation of AT1R signaling by CaV1.2.

Pubmed ID: 28514967

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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