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C-type lectins are important immune molecules that participate in host defense response. The present work reports a novel C-type lectin (PcLec3) from the red swamp crayfish Procambarus clarkii. Sequence analysis found that PcLec3 encodes a polypeptide with252 amino acid residues, which contains an immunoglobulin-like domain (IG) and a C-type lectin domain (CTLD) arranged in tandem. Tissue distribution analysis indicated that PcLec3 is enriched expressed in hemocytes and hepatopancreas cells, in which PcLec3 was up-regulated following bacterial challenge by Vibrio anguillarum. Function analysis using recombinant full-length PcLec3, IG, and CTLD proteins revealed that these recombinant proteins had the capacity to bind carbohydrates and bacteria, while IG determined the cell binding activity. However, only full-length PcLec3 promotes the phagocytic activity of hemocytes and subsequent clearance of invasive bacteria. Taken together, these results manifest that PcLec3 acts as a hemocyte adhesion molecule to promote hemocyte phagocytosis against invasive V. anguillarum.
Pubmed ID: 27411341
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Web search tool to find regions of similarity between biological sequences. Program compares nucleotide or protein sequences to sequence databases and calculates statistical significance. Used for identifying homologous sequences.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE documented on June 4, 2013. Aldente is a tool to identify proteins from peptide mass fingerprinting data. This fast and powerful tool takes advantage of the Hough transform for spectra recalibration and outlier exclusion. The Aldente search form can be used in two modes: for a global view of all the search parameters on one page: click on the section tab All. This global view is useful to have a quick overview before sending the query. to have search parameters grouped into smaller logical sections: click on the corresponding section tab in the tabs banner. Note! Moving from one section to another keeps search parameter selections. For your convenience, you may view / hide the help during your search parameters selection. Use the Help or No help section tab accordingly.
View all literature mentionsA question answer forum for scientists, focusing on methods in bioinformatics, computational genomics and biological data analysis. They welcome detailed and specific posts, written clearly and simply.
View all literature mentionsSoftware tool for identification and annotation of genetically mobile domains and analysis of domain architectures.
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