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RNF8 promotes epithelial-mesenchymal transition of breast cancer cells.

Jingyu Kuang | Li Li | Limei Guo | Yanrong Su | Yuxuan Wang | Yongjie Xu | Xiaozhen Wang | Shucong Meng | Liandi Lei | Luzheng Xu | Genze Shao
Journal of experimental & clinical cancer research : CR | 2016

Epithelial-mesenchymal transition (EMT) is a crucial step for solid tumor progression and plays an important role in cancer invasion and metastasis. RNF8 is an ubiquitin E3 ligase with RING domain, and plays essential roles in DNA damage response and cell cycle regulation. However the role of RNF8 in the pathogenesis of breast cancer is still unclear.

Pubmed ID: 27259701

Research resources used in this publication

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Antibodies used in this publication

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Associated grants

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RRID:MGI:2683685

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