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Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions.

Juan Wang | Jie Hao | Donghui Bai | Qi Gu | Weifang Han | Lei Wang | Yuanqing Tan | Xia Li | Ke Xue | Pencheng Han | Zhengxin Liu | Yundan Jia | Jun Wu | Lei Liu | Liu Wang | Wei Li | Zhonghua Liu | Qi Zhou
Stem cell research & therapy | 2015

Human induced pluripotent stem cells (hiPSCs) are considered as one of the most promising seed cell sources in regenerative medicine. Now hiPSC-based clinical trials are underway. To ensure clinical safety, cells used in clinical trials or therapies should be generated under GMP conditions, and with Xeno-free culture media to avoid possible side effects like immune rejection that induced by the Xeno reagents. However, up to now there are no reports for hiPSC lines developed completely under GMP conditions using Xeno-free reagents.

Pubmed ID: 26564165

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InvivoGen (tool)

RRID:SCR_026997

Biotechnology company in San Diego, California. Provides life scientists with innovative research reagents including immunity and cell culture products.

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