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Differential neutrophil activation in viral infections: Enhanced TLR-7/8-mediated CXCL8 release in asthma.

Francesca S M Tang | David Van Ly | Kirsten Spann | Patrick C Reading | Janette K Burgess | Dominik Hartl | Katherine J Baines | Brian G Oliver
Respirology (Carlton, Vic.) | 2016

Respiratory viral infections are a major cause of asthma exacerbations. Neutrophils accumulate in the airways and the mechanisms that link neutrophilic inflammation, viral infections and exacerbations are unclear. This study aims to investigate anti-viral responses in neutrophils from patients with and without asthma and to investigate if neutrophils can be directly activated by respiratory viruses.

Pubmed ID: 26477783

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