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Northwestern University schizophrenia data sharing for SchizConnect: A longitudinal dataset for large-scale integration.

Alex Kogan | Kathryn Alpert | Jose Luis Ambite | Daniel S Marcus | Lei Wang
NeuroImage | 2016

In this paper, we describe an instance of the Northwestern University Schizophrenia Data and Software Tool (NUSDAST), a schizophrenia-related dataset hosted at XNAT Central, and the SchizConnect data portal used for accessing and sharing the dataset. NUSDAST was built and extended upon existing, standard schemas available for data sharing on XNAT Central (http://central.xnat.org/). With the creation of SchizConnect, we were able to link NUSDAST to other neuroimaging data sources and create a powerful, federated neuroimaging resource.

Pubmed ID: 26087378

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: NIMH NIH HHS, United States
    Id: U01 MH097435
  • Agency: NIMH NIH HHS, United States
    Id: 1U01 MH097435-01A1
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB009352
  • Agency: NIMH NIH HHS, United States
    Id: R01 MH084803
  • Agency: NIMH NIH HHS, United States
    Id: 1R01 MH084803

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This is a list of tools and resources that we have found mentioned in this publication.


Neuroscience Information Framework (tool)

RRID:SCR_002894

Framework for identifying, locating, relating, accessing, integrating, and analyzing information from neuroscience research. Users can search for and add neuroscience-related resources at NIF portal and receive and RRID to track and cite resources within scientific manuscripts.

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NeuroLex (tool)

RRID:SCR_005402

A freely editable semantic wiki for community-based curation of the terms used in Neuroscience. Entries are curated and eventually incorporated into the formal NIFSTD ontology. NeuroLex also includes a Resource branch for community members to freely add neuroscience relevant resources that do not become part of NIFSTD ontology but rather make up the NIF Registry. As part of the NIF, we provide a simple search interface to many different sources of neuroscience information and data. To make this search more effective, we are constructing ontologies to help organize neuroscience concepts into category hierarchies, e.g., neuron is a cell. These categories provide the means to perform more effective searches and also to organize and understand the information that is returned. But an important adjunct to this activity is to clearly define all of the terms that we use to describe our data, e.g., anatomical terms, techniques, organism names. Because wikis provide an easy interface for communities to contribute their knowledge, we started the NeuroLex.

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XNAT Central (tool)

RRID:SCR_006235

Online repository of open access images including MR Sessions, MRI, Freesurfer APARC, Freesurfer ASEGs, Clinical Assessments, Atlas Scaling Factors, and Fast Segmentations data. CENTRAL currently contains 374 Projects, 3808 Subjects, and 5174 Imaging Sessions (June 2014). Central is powered by XNAT (The Extensible Neuroimaging Archive Toolkit), an open source software platform designed to facilitate management and exploration of neuroimaging and related data. XNAT includes a secure database backend and a rich web-based user interface.

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SchizConnect (tool)

RRID:SCR_015766

Platform for mediation and integration of schizophrenia neuroimaging-related databases. It provides access to federated databases, novel mediation software, and large-scale data-sharing features.

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