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Hippocampal subfield surface deformity in non-semantic primary progressive aphasia.

Adam Christensen | Kathryn Alpert | Emily Rogalski | Derin Cobia | Julia Rao | Mirza Faisal Beg | Sandra Weintraub | M-Marsel Mesulam | Lei Wang
Alzheimer's & dementia (Amsterdam, Netherlands) | 2015

Alzheimer neuropathology (AD) is found in almost half of patients with non-semantic primary progressive aphasia (PPA). This study examined hippocampal abnormalities in PPA to determine similarities to those described in amnestic AD.

Pubmed ID: 25893207

Research resources used in this publication

None found

Additional research tools detected in this publication

Antibodies used in this publication

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Associated grants

  • Agency: NIA NIH HHS, United States
    Id: P30 AG013854
  • Agency: NIDCD NIH HHS, United States
    Id: R01 DC008552
  • Agency: NINR NIH HHS, United States
    Id: R01 NR014182
  • Agency: NIA NIH HHS, United States
    Id: P01 AG003991
  • Agency: NIA NIH HHS, United States
    Id: P50 AG005681
  • Agency: NIA NIH HHS, United States
    Id: P01 AG026276
  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR001422
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS075075

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FreeSurfer (tool)

RRID:SCR_001847

Open source software suite for processing and analyzing human brain MRI images. Used for reconstruction of brain cortical surface from structural MRI data, and overlay of functional MRI data onto reconstructed surface. Contains automatic structural imaging stream for processing cross sectional and longitudinal data. Provides anatomical analysis tools, including: representation of cortical surface between white and gray matter, representation of the pial surface, segmentation of white matter from rest of brain, skull stripping, B1 bias field correction, nonlinear registration of cortical surface of individual with stereotaxic atlas, labeling of regions of cortical surface, statistical analysis of group morphometry differences, and labeling of subcortical brain structures.Operating System: Linux, macOS.

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