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Uremic conditions drive human monocytes to pro-atherogenic differentiation via an angiotensin-dependent mechanism.

Bogusz Trojanowicz | Christof Ulrich | Eric Seibert | Roman Fiedler | Matthias Girndt
PloS one | 2014

Elevated expression levels of monocytic-ACE have been found in haemodialysis patients. They are not only epidemiologically linked with increased mortality and cardiovascular disease, but may also directly participate in the initial steps of atherosclerosis. To further address this question we tested the role of monocytic-ACE in promotion of atherosclerotic events in vitro under conditions mimicking those of chronic renal failure.

Pubmed ID: 25003524

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DataAssist (tool)

RRID:SCR_014969

Data analysis tool that utilizes the Comparative CT (ddCT) method to rapidly and accurately quantitate relative gene expression across a large number of genes and samples. Raw input from plates or arrays can be analyzed according to user-determined settings.

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THP-1 (tool)

RRID:CVCL_0006

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HUVEC-C (tool)

RRID:CVCL_2959

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