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Publication

Population pharmacokinetics of trastuzumab emtansine (T-DM1), a HER2-targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer: clinical implications of the effect of covariates.

Dan Lu | Sandhya Girish | Yuying Gao | Bei Wang | Joo-Hee Yi | Ellie Guardino | Meghna Samant | Melody Cobleigh | Mothaffar Rimawi | Pierfranco Conte | Jin Yan Jin
Cancer chemotherapy and pharmacology | 2014

Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate comprising the humanized monoclonal antibody trastuzumab linked to DM1, a highly potent cytotoxic agent. A population pharmacokinetic (PK) analysis was performed to estimate typical values and interindividual variability of T-DM1 PK parameters and the effects of clinically relevant covariates.

Pubmed ID: 24939213

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RRID:SCR_003997

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