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Natural selection of variants within the Arabidopsis thaliana circadian clock can be attributed to adaptation to varying environments. To define a basis for such variation, we examined clock speed in a reporter-modified Bay-0 x Shakdara recombinant inbred line and localized heritable variation. Extensive variation led us to identify EARLY FLOWERING3 (ELF3) as a major quantitative trait locus (QTL). The causal nucleotide polymorphism caused a short-period phenotype under light and severely dampened rhythm generation in darkness, and entrainment alterations resulted. We found that ELF3-Sha protein failed to properly localize to the nucleus, and its ability to accumulate in darkness was compromised. Evidence was provided that the ELF3-Sha allele originated in Central Asia. Collectively, we showed that ELF3 protein plays a vital role in defining its light-repressor action in the circadian clock and that its functional abilities are largely dependent on its cellular localization.
Pubmed ID: 24867215
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Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
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View all literature mentionsA biology and bioinformatics laboratory at the Salk containing the following databases: SIGnAL T-DNA Express Arabidopsis Tiling Array Transcriptome Salk Insertion Sequence Database Arabidopsis Gene ORFeome Collection Salk Homozygote T-DNA Collection High Resolution Arabidopsis Methylome Perlegen Arabidopsis Resequencing Arabidopsis GMUCT Uncapped & Cleaved Transcripts Single Feature Polvmorphism Database High Resolution Arabidopsis Exosome Arabidopsis Interactome Single-base Resolution Epigenome Maps Transgenerational Inheritance of Methylation Variants Arabidopsis Cyclome Rice Functional Genomics Database Salk Arabidopsis 1,001 Genomes Arabidopsis Population Epigenomic Diversity Arabidopsis Biotic Stress Epigenome EIN3 -Ethylene Chip-seq/RNA-seq browser Soybean Epigenome Browser Human Human DNA Methylomes Human Pluripotent Cell Methylomes Human/Mouse Brain Methylomes Mouse Circadian Epigenome
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