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Publication

Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart.

Fuzhong Qin | Deborah A Siwik | Steve Lancel | Jingmei Zhang | Gabriela M Kuster | Ivan Luptak | Lei Wang | Xiaoyong Tong | Y James Kang | Richard A Cohen | Wilson S Colucci
Journal of the American Heart Association | 2013

A hallmark of aging of the cardiac myocyte is impaired sarcoplasmic reticulum (SR) calcium uptake and relaxation due to decreased SR calcium ATPase (SERCA) activity. We tested the hypothesis that H2O2-mediated oxidation of SERCA contributes to impaired myocyte relaxation in aging.

Pubmed ID: 23963753

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: HL-061639
  • Agency: NHLBI NIH HHS, United States
    Id: HL-064750
  • Agency: NHLBI NIH HHS, United States
    Id: P01 HL068758
  • Agency: NHLBI NIH HHS, United States
    Id: P01 HL 068758
  • Agency: NIGMS NIH HHS, United States
    Id: P41 GM104603
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL031607
  • Agency: NHLBI NIH HHS, United States
    Id: HL031607

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FVB/NJ (tool)

RRID:IMSR_JAX:001800

Mus musculus with name FVB/NJ from IMSR.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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