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Expanding the paradigm of thiol redox in the thermophilic root of life.

Joshua Heinemann | Timothy Hamerly | Walid S Maaty | Navid Movahed | Joseph D Steffens | Benjamin D Reeves | Jonathan K Hilmer | Jesse Therien | Paul A Grieco | John W Peters | Brian Bothner
Biochimica et biophysica acta | 2014

The current paradigm of intracellular redox chemistry maintains that cells establish a reducing environment maintained by a pool of small molecule and protein thiol to protect against oxidative damage. This strategy is conserved in mesophilic organisms from all domains of life, but has been confounded in thermophilic organisms where evidence suggests that intracellular proteins have abundant disulfides.

Pubmed ID: 23962628

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Associated grants

  • Agency: NCRR NIH HHS, United States
    Id: P20 RR-020185
  • Agency: NCRR NIH HHS, United States
    Id: P20 RR-024237
  • Agency: NCRR NIH HHS, United States
    Id: P20 RR-16455-08

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METLIN (tool)

RRID:SCR_010500

A public repository of metabolite information as well as tandem mass spectrometry data is provided to facilitate metabolomics experiments. It contains structures and represents a data management system designed to assist in a broad array of metabolite research and metabolite identification. An annotated list of known metabolites and their mass, chemical formula, and structure are available. Each metabolite is linked to outside resources for further reference and inquiry. MS/MS data is also available on many of the metabolites.

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XCMS (tool)

RRID:SCR_015538

Cloud-based mass spectrometry data processing platform for metabolomics and lipidomics.

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