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Publication

Structure-activity relationship studies on the macrolide exotoxin mycolactone of Mycobacterium ulcerans.

Nicole Scherr | Philipp Gersbach | Jean-Pierre Dangy | Claudio Bomio | Jun Li | Karl-Heinz Altmann | Gerd Pluschke
PLoS neglected tropical diseases | 2013

Mycolactones are a family of polyketide-derived macrolide exotoxins produced by Mycobacterium ulcerans, the causative agent of the chronic necrotizing skin disease Buruli ulcer. The toxin is synthesized by polyketide synthases encoded by the virulence plasmid pMUM. The apoptotic, necrotic and immunosuppressive properties of mycolactones play a central role in the pathogenesis of M. ulcerans.

Pubmed ID: 23556027

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NCTC clone 929 (tool)

RRID:CVCL_0462

Cell line NCTC clone 929 is a Spontaneously immortalized cell line with a species of origin Mus musculus

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NCTC clone 929 (tool)

RRID:CVCL_0462

Cell line NCTC clone 929 is a Spontaneously immortalized cell line with a species of origin Mus musculus

View all literature mentions

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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