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Adenosine stimulates the migration of human endothelial progenitor cells. Role of CXCR4 and microRNA-150.

Magali Rolland-Turner | Emeline Goretti | Mélanie Bousquenaud | Frédérique Léonard | Christelle Nicolas | Lu Zhang | Fatiha Maskali | Pierre-Yves Marie | Yvan Devaux | Daniel Wagner
PloS one | 2013

Administration of endothelial progenitor cells (EPC) represents a promising option to regenerate the heart after myocardial infarction, but is limited because of low recruitment and engraftment in the myocardium. Mobilization and migration of EPC are mainly controlled by stromal cell-derived factor 1α (SDF-1α) and its receptor CXCR4. We hypothesized that adenosine, a cardioprotective molecule, may improve the recruitment of EPC to the heart.

Pubmed ID: 23326587

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