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Publication

Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer.

Kelly K Hunt | Hannah Wingate | Tomoya Yokota | Yanna Liu | Gordon B Mills | Fan Zhang | Bingliang Fang | Chun-Hui Su | Ming Zhang | Min Yi | Khandan Keyomarsi
Breast cancer research : BCR | 2013

Elafin is an elastase-specific inhibitor with increased transcription in normal mammary epithelial cells compared to mammary carcinoma cells. In this report, we test the hypothesis that inhibition of elastase, through induction of elafin, leads to inhibition of human breast cancer cell viability and, therefore, predicts survival in breast cancer patients.

Pubmed ID: 23320734

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P30 CA016672
  • Agency: NCI NIH HHS, United States
    Id: R01 CA152228
  • Agency: NCI NIH HHS, United States
    Id: CA016672
  • Agency: NCI NIH HHS, United States
    Id: P50 CA098258
  • Agency: NCI NIH HHS, United States
    Id: 5R01CA087548-10
  • Agency: NCI NIH HHS, United States
    Id: R01 CA087548

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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