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Publication

Interleukin-6 receptor pathways in abdominal aortic aneurysm.

Seamus C Harrison | Andrew J P Smith | Gregory T Jones | Daniel I Swerdlow | Riaz Rampuri | Matthew J Bown | Aneurysm Consortium | Lasse Folkersen | Annette F Baas | Gert Jan de Borst | Jan D Blankensteijn | Jacqueline F Price | Yolanda van der Graaf | Stela McLachlan | Obi Agu | Albert Hofman | Andre G Uitterlinden | Anders Franco-Cereceda | Ynte M Ruigrok | F N van't Hof | Janet T Powell | Andre M van Rij | Juan P Casas | Per Eriksson | Michael V Holmes | Folkert W Asselbergs | Aroon D Hingorani | Steve E Humphries
European heart journal | 2013

We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo. Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach.

Pubmed ID: 23111417

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Associated grants

  • Agency: British Heart Foundation, United Kingdom
    Id: PG/09/022/26739
  • Agency: Medical Research Council, United Kingdom
    Id: G0802432
  • Agency: British Heart Foundation, United Kingdom
    Id: FS 05/125
  • Agency: British Heart Foundation, United Kingdom
    Id: RG2008/08
  • Agency: Wellcome Trust, United Kingdom
    Id: 076113
  • Agency: British Heart Foundation, United Kingdom
    Id: FS/13/6/29977
  • Agency: British Heart Foundation, United Kingdom
    Id: FS/11/16/28696
  • Agency: Wellcome Trust, United Kingdom
    Id: 085475
  • Agency: Chief Scientist Office, United Kingdom
  • Agency: British Heart Foundation, United Kingdom
    Id: RG/10/12/28456

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SMART (tool)

RRID:SCR_005026

Software tool for identification and annotation of genetically mobile domains and analysis of domain architectures.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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