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Publication

Interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells.

Lei Wang | Ziyan Liu | Sivasai Balivada | Tej Shrestha | Stefan Bossmann | Marla Pyle | Loretta Pappan | Jishu Shi | Deryl Troyer
Stem cell research & therapy | 2012

Glioma stem cells (GSCs) have the property of self-renewal and appear to be a driving force for the initiation and recurrence of gliomas. We recently found that the human tumorigenic LN-229 glioma cell line failed to form neurospheres in serum-free conditions and generated mostly small tumors in vivo, suggesting that either LN-229 GSCs are not active in these conditions or GSCs are absent in the LN-229 cell line.

Pubmed ID: 22330721

Research resources used in this publication

None found

Additional research tools detected in this publication

Antibodies used in this publication

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Associated grants

  • Agency: NCRR NIH HHS, United States
    Id: P20-RR017686
  • Agency: NIAID NIH HHS, United States
    Id: R21 AI085416
  • Agency: NCI NIH HHS, United States
    Id: R21CA135599

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

ImageJ (tool)

RRID:SCR_003070

Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

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LN-229 (tool)

RRID:CVCL_0393

Cell line LN-229 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

Crl:NU(NCr)-Foxn1nu (tool)

RRID:IMSR_CRL:490

Mus musculus with name Crl:NU(NCr)-Foxn1nu from IMSR.

View all literature mentions

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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Department of Neurosciences, School of Medicine

University of California, San Diego

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