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Publication

Predicting in vivo anti-hepatofibrotic drug efficacy based on in vitro high-content analysis.

Baixue Zheng | Looling Tan | Xuejun Mo | Weimiao Yu | Yan Wang | Lisa Tucker-Kellogg | Roy E Welsch | Peter T C So | Hanry Yu
PloS one | 2011

Many anti-fibrotic drugs with high in vitro efficacies fail to produce significant effects in vivo. The aim of this work is to use a statistical approach to design a numerical predictor that correlates better with in vivo outcomes.

Pubmed ID: 22073152

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LX-2 (tool)

RRID:CVCL_5792

Cell line LX-2 is a Transformed cell line with a species of origin Homo sapiens

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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