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Retinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro.

Jenny Wegert | Sabrina Bausenwein | Susanne Kneitz | Sabine Roth | Norbert Graf | Eva Geissinger | Manfred Gessler
Molecular cancer | 2011

Wilms tumor (WT) is one of the most common malignancies in childhood. With current therapy protocols up to 90% of patients can be cured, but there is still a need to improve therapy for patients with aggressive WT and to reduce treatment intensity where possible. Prior data suggested a deregulation of the retinoic acid (RA) signaling pathway in high-risk WT, but its mode of action remained unclear.

Pubmed ID: 22067876

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RRID:SCR_006442

Software repository for R packages related to analysis and comprehension of high throughput genomic data. Uses separate set of commands for installation of packages. Software project based on R programming language that provides tools for analysis and comprehension of high throughput genomic data.

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