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Distinctions in gastric cancer gene expression signatures derived from laser capture microdissection versus histologic macrodissection.

Hark Kyun Kim | Joseph Kim | Susie Korolevich | Il Ju Choi | Chang Hee Kim | David J Munroe | Jeffrey E Green
BMC medical genomics | 2011

Gastric cancer samples obtained by histologic macrodissection contain a relatively high stromal content that may significantly influence gene expression profiles. Differences between the gene expression signature derived from macrodissected gastric cancer samples and the signature obtained from isolated gastric cancer epithelial cells from the same biopsies using laser-capture microdissection (LCM) were evaluated for their potential experimental biases.

Pubmed ID: 21635755

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Associated grants

  • Agency: PHS HHS, United States
    Id: HHSN261200800001E
  • Agency: Intramural NIH HHS, United States

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BRB-ArrayTools (tool)

RRID:SCR_010938

An integrated software package for the visualization and statistical analysis of DNA microarray gene expression data.

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