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Publication

Lytic HSV-1 infection induces the multifunctional transcription factor Early Growth Response-1 (EGR-1) in rabbit corneal cells.

Gautam R Bedadala | Jayavardhana R Palem | Lorna Graham | James M Hill | Harris E McFerrin | Shao-Chung Hsia
Virology journal | 2011

Herpes simplex virus type-1 (HSV-1) infections can cause a number of diseases ranging from simple cold sores to dangerous keratitis and lethal encephalitis. The interaction between virus and host cells, critical for viral replication, is being extensively investigated by many laboratories. In this study, we tested the hypothesis that HSV-1 lytic infection triggers the expression of important multi-functional transcription factor Egr1. The mechanisms of induction are mediated, at least in part, by signaling pathways such as NFκB and CREB.

Pubmed ID: 21619646

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Associated grants

  • Agency: NEI NIH HHS, United States
    Id: R01 EY006311
  • Agency: NCRR NIH HHS, United States
    Id: P20 RR016456
  • Agency: NEI NIH HHS, United States
    Id: R15 EY020803
  • Agency: NEI NIH HHS, United States
    Id: EY02377
  • Agency: NCRR NIH HHS, United States
    Id: P20RR016456
  • Agency: NEI NIH HHS, United States
    Id: R15EY020803
  • Agency: NEI NIH HHS, United States
    Id: EY006311
  • Agency: NEI NIH HHS, United States
    Id: R15 EY020803-02
  • Agency: NEI NIH HHS, United States
    Id: P30 EY002377

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HEK293 (tool)

RRID:CVCL_0045

Cell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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