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Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype.

Takashi Sawada | Hideaki Miyoshi | Kohei Shimada | Akira Suzuki | Yuko Okamatsu-Ogura | James W Perfield | Takuma Kondo | So Nagai | Chikara Shimizu | Narihito Yoshioka | Andrew S Greenberg | Kazuhiro Kimura | Takao Koike
PloS one | 2010

Perilipin A (PeriA) exclusively locates on adipocyte lipid droplets and is essential for lipid storage and lipolysis. Previously, we reported that adipocyte specific overexpression of PeriA caused resistance to diet-induced obesity and resulted in improved insulin sensitivity. In order to better understand the biological basis for this observed phenotype, we performed additional studies in this transgenic mouse model.

Pubmed ID: 21103377

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: R01-DK0822574

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Japanese Ministry of Education Culture Sports Science and Technology (MEXT) (tool)

RRID:SCR_011325

One of the eleven Ministries of Japan that composes part of the executive branch of the Government of Japan. Their goal is to improve the development of Japan in relation with the international community.

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Primer Express (tool)

RRID:SCR_014326

Software that allows users to manually or automatically design custom primers and probes for gene quantitation and allelic discrimination (SNP) real-time PCR applications. It supports assays based on TaqMan and SYBR Green I dye chemistries.

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