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Publication

Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.

Francesca Lessi | Andrew Beggs | Mariagrazia de Palo | Marcello Anti | Raffaele Macarone Palmieri | Simona Francesconi | Vito Gomes | Generoso Bevilacqua | Ian Tomlinson | Stefania Segditsas
PloS one | 2010

We have previously shown that serum/glucocorticoid regulated kinase 1 (SGK1) is down-regulated in colorectal cancers (CRC) with respect to normal tissue. As hyper-methylation of promoter regions is a well-known mechanism of gene silencing in cancer, we tested whether the SGK1 promoter region was methylated in colonic tumour samples.

Pubmed ID: 21079778

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Associated grants

  • Agency: Wellcome Trust, United Kingdom
  • Agency: Wellcome Trust, United Kingdom
    Id: 075491/Z/04

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HCT 116 (tool)

RRID:CVCL_0291

Cell line HCT 116 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HT-29 (tool)

RRID:CVCL_0320

Cell line HT-29 is a Cancer cell line with a species of origin Homo sapiens (Human)

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