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Publication

Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells.

Ann H Klopp | Lara Lacerda | Anshul Gupta | Bisrat G Debeb | Travis Solley | Li Li | Erika Spaeth | Wei Xu | Xiaomei Zhang | Michael T Lewis | James M Reuben | Savitri Krishnamurthy | Mauro Ferrari | Rogério Gaspar | Thomas A Buchholz | Massimo Cristofanilli | Frank Marini | Michael Andreeff | Wendy A Woodward
PloS one | 2010

Normal and malignant breast tissue contains a rare population of multi-potent cells with the capacity to self-renew, referred to as stem cells, or tumor initiating cells (TIC). These cells can be enriched by growth as "mammospheres" in three-dimensional cultures.

Pubmed ID: 20808935

Research resources used in this publication

None found

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Antibodies used in this publication

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: CA116199
  • Agency: NCI NIH HHS, United States
    Id: R01 CA138239
  • Agency: NCI NIH HHS, United States
    Id: CA109451
  • Agency: NCI NIH HHS, United States
    Id: P50 CA116199
  • Agency: NCRR NIH HHS, United States
    Id: KL2 RR024149
  • Agency: NCRR NIH HHS, United States
    Id: KL2RR024149
  • Agency: NCI NIH HHS, United States
    Id: R01CA138239-01
  • Agency: NCI NIH HHS, United States
    Id: R01 CA109451
  • Agency: NCI NIH HHS, United States
    Id: R01 CA127857
  • Agency: NCI NIH HHS, United States
    Id: RC1 CA146381
  • Agency: NCI NIH HHS, United States
    Id: RC1CA146381

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MCF-7 (tool)

RRID:CVCL_0031

Cell line MCF-7 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HEK293T (tool)

RRID:CVCL_0063

Cell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)

View all literature mentions

SUM149PT (tool)

RRID:CVCL_3422

Cell line SUM149PT is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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