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Publication

Live-cell super-resolution imaging with trimethoprim conjugates.

Richard Wombacher | Meike Heidbreder | Sebastian van de Linde | Michael P Sheetz | Mike Heilemann | Virginia W Cornish | Markus Sauer
Nature methods | 2010

The spatiotemporal resolution of subdiffraction fluorescence imaging has been limited by the difficulty of labeling proteins in cells with suitable fluorophores. Here we report a chemical tag that allows proteins to be labeled with an organic fluorophore with high photon flux and fast photoswitching performance in live cells. This label allowed us to image the dynamics of human histone H2B protein in living cells at approximately 20 nm resolution.

Pubmed ID: 20693998

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Associated grants

  • Agency: NEI NIH HHS, United States
    Id: PN2 EY016586
  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM036277
  • Agency: NIGMS NIH HHS, United States
    Id: R01GM54469
  • Agency: NIGMS NIH HHS, United States
    Id: RC1GM091804

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H2B-GFP (tool)

RRID:Addgene_11680

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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