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Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types.

Xiang Ling | Diane Calinski | Asher A Chanan-Khan | Muxiang Zhou | Fengzhi Li
Journal of experimental & clinical cancer research : CR | 2010

Survivin is known playing a role in drug resistance. However, its role in bortezomib-mediated inhibition of growth and induction of apoptosis is unclear. There are conflicting reports for the effect of bortezomib on survivin expression, which lacks of a plausible explanation.

Pubmed ID: 20096120

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: CA016056
  • Agency: NCI NIH HHS, United States
    Id: R01 CA109481
  • Agency: NCI NIH HHS, United States
    Id: R01 CA133241

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This is a list of tools and resources that we have found mentioned in this publication.


KMS-11 (tool)

RRID:CVCL_2989

Cell line KMS-11 is a Cancer cell line with a species of origin Homo sapiens (Human)

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p53HCT116 (tool)

RRID:CVCL_S744

Cell line p53HCT116 is a Cancer cell line with a species of origin Homo sapiens (Human)

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PC-3 (tool)

RRID:CVCL_0035

Cell line PC-3 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

MCF-7 (tool)

RRID:CVCL_0031

Cell line MCF-7 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

MDA-MB-231 (tool)

RRID:CVCL_0062

Cell line MDA-MB-231 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions