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Publication

Factors necessary to produce basoapical polarity in human glandular epithelium formed in conventional and high-throughput three-dimensional culture: example of the breast epithelium.

Cedric Plachot | Lesley S Chaboub | Hibret A Adissu | Lei Wang | Albert Urazaev | Jennifer Sturgis | Elikplimi K Asem | Sophie A Lelièvre
BMC biology | 2009

Basoapical polarity in epithelia is critical for proper tissue function, and control of proliferation and survival. Cell culture models that recapitulate epithelial tissue architecture are invaluable to unravel developmental and disease mechanisms. Although factors important for the establishment of basal polarity have been identified, requirements for the formation of apical polarity in three-dimensional tissue structures have not been thoroughly investigated.

Pubmed ID: 19917093

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: CA112017
  • Agency: NCI NIH HHS, United States
    Id: CA112613

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MCF-10A (tool)

RRID:CVCL_0598

Cell line MCF-10A is a Spontaneously immortalized cell line with a species of origin Homo sapiens

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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