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Publication

Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer.

Ern Yu Tan | Leticia Campo | Cheng Han | Helen Turley | Francesco Pezzella | Kevin C Gatter | Adrian L Harris | Stephen B Fox
Breast cancer research : BCR | 2007

Hypoxia-inducible factor (HIF)-1alpha levels in invasive breast carcinoma have been shown to be an adverse prognostic indicator. Cellular HIF-1alpha activity is regulated by factor-inhibiting hypoxia-inducible factor 1 (FIH-1). In hypoxia, FIH-1 hydroxylation of Asn803 within the C-terminal transactivation domain does not occur and HIF-1alpha forms a fully active transcriptional complex. The present study investigates the role of FIH-1 in invasive breast carcinoma and its correlation with hypoxia.

Pubmed ID: 18096060

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COS-1 (tool)

RRID:CVCL_0223

Cell line COS-1 is a Transformed cell line with a species of origin Chlorocebus aethiops (Green monkey)

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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