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Green tea increases anti-inflammatory tristetraprolin and decreases pro-inflammatory tumor necrosis factor mRNA levels in rats.

Heping Cao | Meghan A Kelly | Frank Kari | Harry D Dawson | Joseph F Urban | Sara Coves | Anne M Roussel | Richard A Anderson
Journal of inflammation (London, England) | 2007

Tristetraprolin (TTP/ZFP36) family proteins have anti-inflammatory activity by binding to and destabilizing pro-inflammatory mRNAs such as Tnf mRNA, and represent a potential therapeutic target for inflammation-related diseases. Tea has anti-inflammatory properties but the molecular mechanisms have not been completely elucidated. We hypothesized that TTP and/or its homologues might contribute to the beneficial effects of tea as an anti-inflammatory product.

Pubmed ID: 17207279

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