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High yield recombinant penicillin G amidase production and export into the growth medium using Bacillus megaterium.

Yang Yang | Rebekka Biedendieck | Wei Wang | Martin Gamer | Marco Malten | Dieter Jahn | Wolf-Dieter Deckwer
Microbial cell factories | 2006

During the last years B. megaterium was continuously developed as production host for the secretion of proteins into the growth medium. Here, recombinant production and export of B. megaterium ATCC14945 penicillin G amidase (PGA) which is used in the reverse synthesis of beta-lactam antibiotics were systematically improved.

Pubmed ID: 17132166

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Cold Spring Harbor Laboratory (tool)

RRID:SCR_008326

Non profit, private research and education institution that performs molecular and genetic research used to generate methods for better diagnostics and treatments for cancer and neurological diseases. Research of cancer causing genes and their respective signaling pathways, mutations and structural variations of the human genome that could cause neurodevelopmental and neurodegenerative illnesses such as autism, schizophrenia, and Alzheimer's and Parkinson's diseases and also research in plant genetics and quantitative biology.

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