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Publication

Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs.

Wendong Yu | Yan Wang | Chad A Shaw | Xiao-Feng Qin | Andrew P Rice
Retrovirology | 2006

P-TEFb, a general RNA polymerase II elongation factor, is composed of CDK9 (cyclin-dependent kinase 9) as a catalytic unit and either cyclin T1, T2 or K as a regulatory subunit. The cyclin T1/P-TEFb complex is targeted by HIV to mediate Tat transactivation. Cyclin T1 protein expression is induced during early macrophage differentiation, suggesting a role in regulation of mRNA expression during the differentiation process. To study the functional significance of cyclin T1 induction during differentiation, we utilized the human Mono Mac 6 (MM6) monocytic cell line.

Pubmed ID: 16764723

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Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: AI45374
  • Agency: NIAID NIH HHS, United States
    Id: R01 AI045374
  • Agency: NIAID NIH HHS, United States
    Id: R21 AI045374
  • Agency: NIAID NIH HHS, United States
    Id: R01 AI035381
  • Agency: NIAID NIH HHS, United States
    Id: AI35381
  • Agency: NIAID NIH HHS, United States
    Id: R56 AI035381

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HEK293T (tool)

RRID:CVCL_0063

Cell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)

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HEK293 (tool)

RRID:CVCL_0045

Cell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)

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