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Discovery of Time-Delayed Gene Regulatory Networks based on temporal gene expression profiling.

Xia Li | Shaoqi Rao | Wei Jiang | Chuanxing Li | Yun Xiao | Zheng Guo | Qingpu Zhang | Lihong Wang | Lei Du | Jing Li | Li Li | Tianwen Zhang | Qing K Wang
BMC bioinformatics | 2006

It is one of the ultimate goals for modern biological research to fully elucidate the intricate interplays and the regulations of the molecular determinants that propel and characterize the progression of versatile life phenomena, to name a few, cell cycling, developmental biology, aging, and the progressive and recurrent pathogenesis of complex diseases. The vast amount of large-scale and genome-wide time-resolved data is becoming increasing available, which provides the golden opportunity to unravel the challenging reverse-engineering problem of time-delayed gene regulatory networks.

Pubmed ID: 16420705

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: P50 HL077101
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL066251
  • Agency: NHLBI NIH HHS, United States
    Id: P50 HL077101-01

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Cold Spring Harbor Laboratory (tool)

RRID:SCR_008326

Non profit, private research and education institution that performs molecular and genetic research used to generate methods for better diagnostics and treatments for cancer and neurological diseases. Research of cancer causing genes and their respective signaling pathways, mutations and structural variations of the human genome that could cause neurodevelopmental and neurodegenerative illnesses such as autism, schizophrenia, and Alzheimer's and Parkinson's diseases and also research in plant genetics and quantitative biology.

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