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Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach.

Jonathan P Katz | Nathalie Perreault | Bree G Goldstein | Lori Actman | Sara R McNally | Debra G Silberg | Emma E Furth | Klaus H Kaestner
Gastroenterology | 2005

The epithelial zinc-finger transcription factor Klf4 (formerly GKLF) regulates cellular proliferation and differentiation in vitro. Klf4 null mice die by postnatal day 1 and show changes in epithelial differentiation of skin and colon.

Pubmed ID: 15825076

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: K08 DK002809-04
  • Agency: NIDDK NIH HHS, United States
    Id: P01 DK049210
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK05306-07
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK053839-06
  • Agency: NIDDK NIH HHS, United States
    Id: R03 DK062850-01

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