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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: PROM1
Genomic Alteration: Transgene: wild type human PROML1
Notes: Application: Study of Eye Disorders
Proper citation: RRID:NSRRC_0055 Copy
The record is no longer available at this source.
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: SMN
Notes: SMN Knockout
Proper citation: RRID:NSRRC_0063 Copy
The record is no longer available at this source.
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: FAH
Notes: FAH Knockout via zygote injection of the CRISPR Cas-9 system.
Proper citation: RRID:NSRRC_0062 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Yucatan
Affected Genes: NOS3
Genomic Alteration: Transgene: Tie2 promoter driving endothelial Nitrate Oxide Synthase (NOS3)
Source References: PMID:17080303
Notes: Application: Cardiovascular, Exercise Physiology
Proper citation: RRID:NSRRC_0021 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Yucatan
Affected Genes: Green Fluorescent Protein
Genomic Alteration: Transgene: CAG promoter driving the enhanced green fluorescent protein
Notes: Application: Cell Tracking
Proper citation: RRID:NSRRC_0020 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Yucatan
Affected Genes: CAT
Genomic Alteration: Transgene: Human Catalase (CAT)
Source References: PMID:21170678
Notes: Application: Cardiovascular, Exercise Physiology
Proper citation: RRID:NSRRC_0022 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: GGTA1, CD39, CD55, CD59
Genomic Alteration: GGTA1 knockout, with three randomly integrated transgenes: human decay-accelerating factor (CD55), CD39, CD59 and thrombomodulin
Notes: Application: Xenotransplantation
Proper citation: RRID:NSRRC_0025 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Minnesota Mini
Affected Genes: PSMA1
Genomic Alteration: Transgene: GFP-Proteasome Fusion Protein (PSMA1)
Source References: PMID:23550158
Notes: Application: Proteasome research
Proper citation: RRID:NSRRC_0024 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Minnesota Mini
Affected Genes: Green Fluorescent Protein
Genomic Alteration: Transgene: Ubiquitin C (UBC) promoter driving Nuclear Localized eGFP
Notes: Application: Cell Tracking
Proper citation: RRID:NSRRC_0032 Copy
The record is no longer available at this source.
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: FANCD2
Notes: Monoallelic KO of FANCD2 via zygote injection of the CRISPR Cas-9 system. A biallelic modification is embryonic lethal.
Proper citation: RRID:NSRRC_0076 Copy
https://nsrrc.missouri.edu/nsrrc0070-anpep/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: ANPEP
Notes: Knockout of gene function via zygote injection of the CRISPR Cas-9 system. Homozygous and heterozygous available.
Proper citation: RRID:NSRRC_0070 Copy
https://nsrrc.missouri.edu/nsrrc0072-antxr1/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: ANTXR1
Notes: Monoallelic in-frame mutation via zygote injection of the CRISPR Cas-9 system. Available in semen and fetal fibroblast.
Proper citation: RRID:NSRRC_0072 Copy
https://nsrrc.missouri.edu/nsrrc0071-cd163/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: CD163
Notes: Knockout of gene function via zygote injection of the CRISPR Cas-9 system. Homozygous and heterozygous available.
Proper citation: RRID:NSRRC_0071 Copy
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