Searching the RRID Resource Information Network
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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
The record is no longer available at this source.
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: FANCA
Notes: KO of FANCA Exon 4 via zygote injection of the CRISPR Cas-9 system.
Proper citation: RRID:NSRRC_0075 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Minnesota Mini
Affected Genes: GGTA1 and CD55
Genomic Alteration: GGTA1 knockout with a transgene for human decay-accelerating factor (CD55) inserted into GGTA1
Notes: Application: Xenotransplantation studies
Proper citation: RRID:NSRRC_0037 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Yucatan
Affected Genes: DMD
Genomic Alteration: Deletion of Exon 42 of DMD
Notes: Application: Becker muscular dystrophyÂ
Proper citation: RRID:NSRRC_0034 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Minnesota Mini
Affected Genes: KRASG12D and p53R172H
Genomic Alteration: Transgene: CAG LoxP Stop driving KRASG12D and p53R172H
Source References: PMID:26132737
Notes: Application: Inducible Cancer Model
Proper citation: RRID:NSRRC_0033 Copy
The record is no longer available at this source.
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: USH2A
Notes: Both biallelic and monoallelic knockout of the USH2A gene via zygote injections of the CRISPR Cas-9 system. This induces Usher Syndrome Type 2. Available in fetal fibroblast.
Proper citation: RRID:NSRRC_0077 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: BRCA1
Genomic Alteration: Transgene: CSN2 promoter driving micro RNAs directed against BRAC1 and RASSF1
Notes: Application: Breast Cancer model
Proper citation: RRID:NSRRC_0036 Copy
https://nsrrc.missouri.edu/nsrrc-0079-clca1-ko/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: CLCA1
Notes: KO of the CLCA1 gene via zygote injections of the CRISPR Cas-9 system, to reduce mucus production in the lungs.
Proper citation: RRID:NSRRC_0079 Copy
The record is no longer available at this source.
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: FAH, RAG2
Notes: A biallelic knockout of both FAH and RAG2 genes, using the CRISPR Cas-9 system in zygote injections and electroporation.
Proper citation: RRID:NSRRC_0085 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: ISL1
Genomic Alteration: Transgene: ISL1 - tissue specific expression of CRE
Notes: Application: Cardiovascular
Proper citation: RRID:NSRRC_0040 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Genomic Alteration: wildtype
Notes: Application: background strain
Proper citation: RRID:NSRRC_0043 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Genomic Alteration: wildtype
Notes: Application: background strain
Proper citation: RRID:NSRRC_0042 Copy
The record is no longer available at this source.
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: SAP130
Notes: Monoallelic knockout of the SAP130 gene via zygote injections of the CRISPR Cas-9 system. A biallelic modification is embryonic lethal. Available in fetal fibroblast.
Proper citation: RRID:NSRRC_0081 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: ELOVL4
Genomic Alteration: Transgene: ELOVL4 Y270X with the enhanced yellow fluorescent protein
Source References: PMID:21873315
Notes: Application: Study of Eye Disorders
Proper citation: RRID:NSRRC_0049 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Genomic Alteration: wildtype
Notes: Application: Background for genetic modification
Proper citation: RRID:NSRRC_0004 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Genomic Alteration: wildtype
Notes: Application: Background for genetic modification
Proper citation: RRID:NSRRC_0003 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: RHO
Genomic Alteration: Transgene: Pro347Ser in RHO
Source References: PMID:16402026
Notes: Application: Study of Eye Disorders
Proper citation: RRID:NSRRC_0046 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Genomic Alteration: wildtype
Notes: Application: Background for genetic modification
Proper citation: RRID:NSRRC_0002 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: inbred
Genomic Alteration: wildtype
Source References: PMID:19434740
Notes: Application: Background for genetic modification,obesity, diabetes, cardiovascular, Polycystic Ovarian Syndrome
Proper citation: RRID:NSRRC_0008 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: PROM1
Genomic Alteration: Transgene: wild type human PROML1
Notes: Application: Study of Eye Disorders
Proper citation: RRID:NSRRC_0054 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: inbred
Genomic Alteration: wildtype
Source References: PMID:3534436
Notes: Application: small porcine model as background for genetic modification
Proper citation: RRID:NSRRC_0012 Copy
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