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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: inbred
Genomic Alteration: wildtype
Source References: PMID:137560
Notes: Application: research in the areas of immune system, and xenotransplantation
Proper citation: RRID:NSRRC_0015 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: FVIII, FURIN, SERPINA1
Genomic Alteration: Transgenes: Human coagulation factor VIII, Human alpha 1-antitrypsin, Propeptide cleavage enzyme (PACE/FURIN)
Notes: Application: Hemophilia Research
Proper citation: RRID:NSRRC_0018 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: NIHc/c
Affected Genes: RHO
Genomic Alteration: Transgene: Rhodopsin (RHO) P23H substitution
Source References: PMID:22247487
Notes: Application: Study of Retinitis Pigmentosa
Proper citation: RRID:NSRRC_0017 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: PROM1
Genomic Alteration: Transgene: wild type human PROML1
Notes: Application: Study of Eye Disorders
Proper citation: RRID:NSRRC_0056 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: FAT1
Genomic Alteration: Transgene: expression of hFAT1
Source References: PMID:16565727
Notes: Application: research in the areas of reproduction, cardiovascular, immune system, depression and cancer
Proper citation: RRID:NSRRC_0011 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: inbred
Genomic Alteration: wildtype
Source References: PMID:137560
Notes: Application: research in the areas of immune system, and xenotransplantation
Proper citation: RRID:NSRRC_0014 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: C1QTNF5 (CTRP)
Genomic Alteration: Transgene: S163R mutation of pig CTRP (C1QTNF5)
Notes: Application: Study of Eye Disorders
Proper citation: RRID:NSRRC_0058 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: inbred
Genomic Alteration: wildtype
Source References: PMID:137560
Notes: Application: research in the areas of immune system, and xenotransplantation
Proper citation: RRID:NSRRC_0013 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: C1QTNF5 (CTRP)
Genomic Alteration: Transgene: S163R mutation of pig CTRP (C1QTNF5)
Notes: Application: Study of Eye Disorders
Proper citation: RRID:NSRRC_0057 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: FIX, FURIN, VWF
Genomic Alteration: Transgenes: Human coagulation factor IX, Human alpha 1-antitrypsin, von Willibrand factor
Notes: Application: Hemophilia Research
Proper citation: RRID:NSRRC_0019 Copy
https://nsrrc.missouri.edu/nsrrc0064-apc/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Minnesota Mini
Affected Genes: APC
Notes: Heterozygous modification of the Adenomatous polyposis coli(APC)gene to induce colorectal polyps
Proper citation: RRID:NSRRC_0064 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Minnesota Mini
Affected Genes: GGTA1
Genomic Alteration: GGTA1 knockout with human decay-accelerating factor (CD55) and CD39 transgenes inserted into GGTA1
Notes: Application: Xenotransplantation
Proper citation: RRID:NSRRC_0061 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: TMPRSS2
Genomic Alteration: TMPRSS2 knockout
Notes: Application: Immune system
Proper citation: RRID:NSRRC_0060 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Minnesota Mini
Affected Genes: tdTomato
Genomic Alteration: Transgene: CAG promoter driving tdTomato
Notes: Application: Cell Tracking
Proper citation: RRID:NSRRC_0027 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Minnesota Mini
Affected Genes: Green Fluorescent Protein
Genomic Alteration: Transgene: CAG promoter driving a Nuclear localized enhanced Green fluorescent Protein
Notes: Application: Cell Tracking
Proper citation: RRID:NSRRC_0026 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: TK1
Genomic Alteration: Transgene: Albumin (ALB) promoter driving Thymidine Kinase (TK1)
Notes: Application: Liver Research
Proper citation: RRID:NSRRC_0029 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: outbred
Affected Genes: CDA
Genomic Alteration: Transgene: Alpha fetoprotein (AFP) promoter driving cytidine deaminase (CDA)
Notes: Application: Liver Research
Proper citation: RRID:NSRRC_0028 Copy
https://nsrrc.missouri.edu/nsrrc0069-siglec1-cd169/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: domestic
Affected Genes: SIGLEC1
Notes: Insertion of a transgene harboring neomycin resistance into the SIGLEC1 gene through homologous recombination, knocking out gene function. Obtained through somatic cell nuclear transfer and propagated by breeding. Homozygous and heterozygous available.
Proper citation: RRID:NSRRC_0069 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Minnesota Mini
Affected Genes: ZP3-CRE-CRE
Genomic Alteration: Transgene: Zona Pecullida 3 (ZP3) promoter driving CRE-eGFP
Notes: Application: Cell Tracking
Proper citation: RRID:NSRRC_0030 Copy
https://nsrrc.missouri.edu/StrainAvail/
Source Database: NSRRC, National Swine Resource and Research Center (NSRRC)
Genetic Background: Minnesota Mini
Affected Genes: tdTomato
Genomic Alteration: Transgene: Ubiquitin C (UBC) promoter driving tdTomato
Notes: Application: Cell Tracking
Proper citation: RRID:NSRRC_0031 Copy
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