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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
cisTEM
 
Resource Report
Resource Website
50+ mentions
cisTEM (RRID:SCR_016502) cisTEM software application, image processing software, software resource, data processing software Software to process cryo-EM images of macromolecular complexes and obtain high-resolution 3D reconstructions from them. data, processing, high, resolution, electron, cryo, macroscopy, single, particle, averaging, image, macromolecule, high, resolution, 3D, bio.tools is listed by: bio.tools
is listed by: Debian
Howard Hughes Medical Institute DOI:10.7554/eLife.35383 Open source, Trial available biotools:cistem https://bio.tools/cistem SCR_016502 computational imaging system for Transmission Electron Microscopy 2026-07-27 09:35:19 64
EMAN
 
Resource Report
Resource Website
100+ mentions
EMAN (RRID:SCR_016867) EMAN software application, image processing software, software resource, data processing software Software suite for processing data from transmission electron microscopes. Used in supercomputing facilities as a test application for large-scale computing. Used for single particle reconstruction, helical reconstruction, 2-D crystallography and whole-cell tomography. image, processing, data, transmission, electron, microscope, single, particle, reconstruction, helical, 2D, whole, cell, tomography, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
NIH PMID:16859925 Free, Available for download, Freely available biotools:eman https://bio.tools/eman https://blake.bcm.edu/emanwiki/EMAN1 SCR_016867 EMAN1, EMAN2 2026-07-27 09:35:27 106
Experimental Design Assistant
 
Resource Report
Resource Website
100+ mentions
Experimental Design Assistant (RRID:SCR_017019) EDA service resource, web application, software resource Web based tool to help in vivo researchers improve design, conduct, analysis and reporting of animal experiments.Provides automated feedback on proposed design and generates graphical summary that aids communication with colleagues, founders and regulatory authorities. Addresses causes of irreproducibility. in vivo, design, conduct, analysis, reporting, animal, experiment, irreproducibility, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: NC3Rs
PMID:28957312 Free, Freely available biotools:eda https://bio.tools/eda SCR_017019 EDA, Experimental Design Assistant (EDA), Experimental Design Assistant 2026-07-27 09:35:24 187
NNcon
 
Resource Report
Resource Website
1+ mentions
NNcon (RRID:SCR_014292) prediction, software tool Protein contact map prediction is useful for protein folding rate prediction, model selection and 3D structure prediction. Here we describe NNcon, a fast and reliable contact map prediction server and software. NNcon was ranked among the most accurate residue contact predictors in the Eighth Critical Assessment of Techniques for Protein Structure Prediction (CASP8), 2008. text mining objective, bio.tools is listed by: Debian
is listed by: bio.tools
PMID:19420062 biotools:nncon https://bio.tools/nncon http://casp.rnet.missouri.edu/nncon.html SCR_014292 2026-07-27 09:34:36 2
GOEAST - Gene Ontology Enrichment Analysis Software Toolkit
 
Resource Report
Resource Website
10+ mentions
GOEAST - Gene Ontology Enrichment Analysis Software Toolkit (RRID:SCR_006580) GOEAST analysis service resource, service resource, data analysis service, production service resource Gene Ontology Enrichment Analysis Software Toolkit (GOEAST) is a web based software toolkit providing easy to use, visualizable, comprehensive and unbiased Gene Ontology (GO) analysis for high-throughput experimental results, especially for results from microarray hybridization experiments. The main function of GOEAST is to identify significantly enriched GO terms among give lists of genes using accurate statistical methods. Compared with available GO analysis tools, GOEAST has the following unique features: * GOEAST supports analysis for data from various resources, such as expression data obtained using Affymetrix, illumina, Agilent or customized microarray platforms. GOEAST also supports non-microarray based experimental data. The web-based feature makes GOEAST very user friendly; users only have to provide a list of genes in correct formats. * GOEAST provides visualizable analysis results, by generating graphs exhibiting enriched GO terms as well as their relationships in the whole GO hierarchy. * Note that GOEAST generates separate graph for each of the three GO categories, namely biological process, molecular function and cellular component. * GOEAST allows comparison of results from multiple experiments (see Multi-GOEAST tool). The displayed color of each GO term node in graphs generated by Multi-GOEAST is the combination of different colors used in individual GOEAST analysis. Platform: Online tool statistical analysis, gene ontology, high-throughput, microarray, hybridization, gene, visualization, bio.tools is listed by: Gene Ontology Tools
is listed by: Debian
is listed by: bio.tools
is related to: Gene Ontology
has parent organization: Chinese Academy of Sciences; Beijing; China
National Natural Science Foundation of China 30725014;
National Natural Science Foundation of China 90612019;
Ministry of Science and Technology of China 2007CB946901;
Chinese Academy of Sciences KSCX2-YW-R-134;
Chinese Academy of Sciences KSCX2-YW-N-024
PMID:18487275 Free for academic use biotools:goeast, nlx_149248 https://bio.tools/goeast SCR_006580 Gene Ontology Enrichment Analysis Software Toolkit, Gene Ontology Enrichment Analysis Software Toolkit (GOEAST) 2026-07-27 09:32:35 38
NEBcutter
 
Resource Report
Resource Website
100+ mentions
NEBcutter (RRID:SCR_010664) analysis service resource, service resource, data analysis service, production service resource This tool will take a DNA sequence and find the large, non-overlapping open reading frames using the E.coli genetic code and the sites for all Type II and commercially available Type III restriction enzymes that cut the sequence just once. By default, only enzymes available from NEB are used, but other sets may be chosen. Just enter your sequence and submit. Further options will appear with the output. The maximum size of the input file is 1 MByte, and the maximum sequence length is 300 KBases. NEBcutter produces a variety of outputs including restriction enzyme maps, theoretical digests and links into the restriction enzyme database, REBASE (http://rebase.neb.com/rebase/rebase.html). Importantly, its table of recognition sites is updated daily from REBASE and it marks all sites that are potentially affected by DNA methylation (Dam, Dcm, etc.). Many options exist to choose the enzymes used for digestion, including all known specificities, subsets of those that are commercially available or sets of enzymes that produce compatible termini. bio.tools, FASEB list is listed by: Debian
is listed by: bio.tools
has parent organization: New England Biolabs
PMID:12824395 biotools:nebcutter, nlx_71778 https://bio.tools/nebcutter SCR_010664 2026-07-27 09:33:49 142
Single Nucleotide Polymorphism Spectral Decomposition (SNPSpD)
 
Resource Report
Resource Website
10+ mentions
Single Nucleotide Polymorphism Spectral Decomposition (SNPSpD) (RRID:SCR_008621) SNPSpD analysis service resource, service resource, data analysis service, production service resource SNPSpD is a method of correcting for non-independance of single nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) with each other, on the basis of the spectral decomposition (SpD) of matrices of LD between SNP''s. Additionally, output from SNPSpD includes eigenvalues, principal-component coefficients, and factor loadings after varimax rotation, enabling the selection of a subset of SNPs that optimize the information in a genomic region. bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: Queensland Institute of Medical Research
National Health and MRC Australia 241916 PMID:14997420 biotools:snpspd, nif-0000-31985 https://bio.tools/snpspd http://genepi.qimr.edu.au/general/daleN/SNPSp SCR_008621 Single Nucleotide Polymorphism Spectral Decomposition 2026-07-27 09:33:09 18
Webproanalyst
 
Resource Report
Resource Website
Webproanalyst (RRID:SCR_008348) analysis service resource, service resource, data analysis service, production service resource WebProAnalyst provides web-accessible analysis for scanning the quantitative structure-activity relationships in protein families. It searches for a sequence region, whose substitutions are correlated with variations in the activities of a homologous protein set, the so-called activity modulating sites. WebProAnalyst allows users to search for the key physicochemical characteristics of the sites that affect the changes in protein activities. It enables the building of multiple linear regression and neural networks models that relate these characteristics to protein activities. WebProAnalyst implements multiple linear regression analysis, back propagation neural networks and the Structure-Activity Correlation/Determination Coefficient (SACC/SADC). A back propagation neural network is implemented as a two-layered network, one layer as input, the other as output (Rumelhart et al, 1986). WebProAnalyst uses alignment of amino acid sequences and data on protein activity (pK, Km, ED50, among others). The input data are the numerical values for the physicochemical characteristics of a site in the multiple alignment given by a slide window. The output data are the predicted activity values. The current version of WebProAnalyst handles a single activity for a single protein. The SACC/SADC may be defined as an estimate of the strongest multiple correlation between the physicochemical characteristics of a site in a multiple alignment and protein activities. The SACC/SADC coefficient makes possible the calculation of the possible highest correlation achievable for the quantitative relationship between the physicochemical properties of sites and protein activities. The SACC/SADC is a convenient means for an arrangement of positions by their functional significance. WebProAnalyst outputs a list of multiple alignment positions, the respective correlation values, also regression analysis parameters for the relationships between the amino acid physicochemical characteristics at these positions and the protein activity values. family, functional, activity, alignment, amino acid, homologous, modulating site, neural, physicochemical, propagation, protein, quantitative, region, relationship, scan, sequence, structure, substitution, variation, bio.tools is listed by: bio.tools
is listed by: Debian
nif-0000-25212, biotools:webproanalyst https://bio.tools/webproanalyst SCR_008348 Webproanalyst 2026-07-27 09:33:04 0
ComiR
 
Resource Report
Resource Website
10+ mentions
ComiR (RRID:SCR_013023) ComiR analysis service resource, service resource, data analysis service, production service resource Data analysis service that predicts whether a given mRNA is targeted by a set of miRNAs. ComiR uses miRNA expression to improve and combine multiple miRNA targets for each of the four prediction algorithms: miRanda, PITA, TargetScan and mirSVR. The composite scores of the four algorithms are then combined using a support vector machine trained on Drosophila Ago1 IP data. mirna, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Pittsburgh; Pennsylvania; USA
NLM ;
Fondazione RiMED
PMID:23703208
PMID:23284279
Acknowledgement requested OMICS_00395, biotools:comir https://bio.tools/comir SCR_013023 Combinatorial miRNA targeting, ComiR: Combinatorial miRNA target prediction tool, ComiR - Combinatorial miRNA target prediction tool 2026-07-27 09:34:19 26
omiRas
 
Resource Report
Resource Website
10+ mentions
omiRas (RRID:SCR_010833) omiRas analysis service resource, service resource, data analysis service, production service resource A web server for the annotation, comparison and visualization of interaction networks of non-coding RNAs derived from small RNA-Sequencing experiments of two different conditions. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:23946503 biotools:omiras, OMICS_00383 https://bio.tools/omiras SCR_010833 2026-07-27 09:33:49 14
MutationTaster
 
Resource Report
Resource Website
1000+ mentions
MutationTaster (RRID:SCR_010777) MutationTaster analysis service resource, service resource, data analysis service, production service resource Evaluates disease-causing potential of sequence alterations. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
PMID:20676075 Acknowledgement requested biotools:mutation_taster, OMICS_00153 https://bio.tools/mutation_taster SCR_010777 2026-07-27 09:33:49 4180
GenoREAD
 
Resource Report
Resource Website
GenoREAD (RRID:SCR_012007) GenoREAD analysis service resource, service resource, data analysis service, production service resource A sequence verification pipeline where users can submit trace files to verify if a clone''s physical sequence matches its reference sequence. clone, verification, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Virginia Bioinformatics Institute
PMID:23042248 Acknowledgement requested OMICS_01823, biotools:genoread https://bio.tools/genoread SCR_012007 GenoREAD - Sequencing Verification Pipeline 2026-07-27 09:34:00 0
DSAP
 
Resource Report
Resource Website
1+ mentions
DSAP (RRID:SCR_013352) DSAP analysis service resource, service resource, data analysis service, production service resource A web server designed to provide a total solution to analyze small RNAs sequencing data generated by SOLEXA., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:20478825 THIS RESOURCE IS NO LONGER IN SERVICE biotools:dsap, OMICS_00357 https://bio.tools/dsap SCR_013352 2026-07-27 09:34:23 8
PubCrawler
 
Resource Report
Resource Website
1+ mentions
PubCrawler (RRID:SCR_008235) service resource, software resource PubCrawler is a free alerting service that scans daily updates to the NCBI Medline (PubMed) and GenBank databases. PubCrawler helps keeping scientists informed of the current contents of Medline and GenBank, by listing new database entries that match their research interests. The free PubCrawler web service has been operating for five years and so far has brought literature and sequence updates to over 22 000 users. It provides information on a personalized web page whenever new articles appear in PubMed or when new sequences are found in GenBank that are specific to customized queries. The server also acts as an automatic alerting system by sending out short notifications or emails with the latest updates as soon as they become available. PubCrawler searches the NCBI PubMed (Medline) and Entrez (GenBank) databases daily using search parameters (keywords, author names, etc.) specified by the user. There is no limit on the number of searches that can be carried out. Previous search hits are stored and only the newest PubMed or GenBank records are shown each day. The results are presented as an HTML Web page, similar to the results of an NCBI PubMed or Entrez query. This Web page can be located on our computer (the PubCrawler WWW-Service), on your computer (the stand-alone program), or you can receive it via e-mail (set this up using the PubCrawler WWW-Service). The Web page sorts the results into groups of PubMed/GenBank entries that are zero-days-old, 1-day-old, 2-days-old, etc., up to a user-specified age limit. Sponsors: Development of PubCrawler was supported by EMBnet training tools, bio.tools is listed by: 3DVC
is listed by: bio.tools
is listed by: Debian
biotools:pubcrawler, nif-0000-21345 https://bio.tools/pubcrawler SCR_008235 PubCrawler 2026-07-27 09:33:01 9
Yabi
 
Resource Report
Resource Website
Yabi (RRID:SCR_005359) Yabi service resource, software resource A web-based analytical environment framework for bioinformatics applications that can be customized for a diverse range of -omics applications. The software system is adaptable to a range of both pluggable execution and data backends in an open source implementation. Enabling seamless and transparent access to heterogenous HPC environments at its core, it then provides an analysis workflow environment that can create and reuse workflows as well as manage large amounts of both raw and processed data in a secure and flexible way across geographically distributed compute resources. Yabi can be used via a web-based environment to drag-and-drop tools to create sophisticated workflows. It can also be accessed through the Yabi command line which is designed for users that are more comfortable with writing scripts or for enabling external workflow environments to leverage the features in Yabi. Configuring tools can be a significant overhead in workflow environments. Yabi greatly simplifies this task by enabling system administrators to configure as well as manage running tools via a web-based environment and without the need to write or edit software programs or scripts. grid computing, high performance computing, cloud computing, bioinformatics, pipeline, workflow, command line, python, linux, storage, compute, genomics, transcriptomics, proteomics, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Murdoch University; Perth; Australia
PMID:22333270 GNU General Public License, v3 OMICS_01148, biotools:yabi https://bio.tools/yabi SCR_005359 2026-07-27 09:32:15 0
imDEV
 
Resource Report
Resource Website
1+ mentions
imDEV (RRID:SCR_014674) software application, systems interoperability software, software resource A software application of RExcel that integrates R into Excel as an embedded additon for omics tasks and analysis. It can be used specifically for tasks concerning multivariate data visualization, exploration, and analysis. imDev has interactive modules for dimensional reduction, prediction, feature selection, analysis of correlation, and generation of networked structures, all of which provide an integrated environment for systems level analysis of multivariate data. statistical analysis, statistical analysis package, r, r package, excel, data visualization, feature selection, omics, systems interoperability, software, metabolomics, bio.tools is listed by: Metabolomics Workbench
is listed by: Debian
is listed by: bio.tools
DOI:10.1093/bioinformatics/bts439 Supports Microsoft Excel versions 2003-2010 biotools:imdev https://sourceforge.net/projects/imdev/, https://bio.tools/imdev SCR_014674 Interactive modules for Data Exploration and Visualization, Interactive modules for Data Exploration and Visualization (imDEV) 2026-07-27 09:34:42 8
Chromas
 
Resource Report
Resource Website
10+ mentions
Chromas (RRID:SCR_000598) Chromas commercial organization, software resource Software ideal for the most basic of sequencing projects, where assembly of multiple sequences is not required., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. sequencing, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01016, biotools:chromas https://bio.tools/chromas SCR_000598 2026-07-27 09:31:00 16
QuPath
 
Resource Report
Resource Website
1000+ mentions
QuPath (RRID:SCR_018257) software application, image analysis software, software resource, data processing software Open Source software package for digital pathology image analysis. Used for whole slide image analysis and digital pathology. Provides researchers with batch processing and scripting functionality, and extensible platform with which to develop and share new algorithms to analyze complex tissue images. Digital pathology, image analysis, whole slide image, batch processing, tissue image, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: Queens University Belfast; Ireland; United Kingdom
Invest Northern Ireland ;
Experimental Cancer Medicine Centre Network ;
Sean Crummey Memorial Fund ;
Tom Simms Memorial Fund ;
Friends of the Cancer Centre ;
Cancer Research UK Accelerator
PMID:29203879 Free, Available for download, Freely available biotools:qupath https://bio.tools/qupath SCR_018257 2026-07-27 09:35:42 1590
GeSeq
 
Resource Report
Resource Website
100+ mentions
GeSeq (RRID:SCR_017336) software application, service resource, software resource, data processing software Software tool for rapid and accurate annotation of organelle genomes, in particular chloroplast genomes. rapid, accurate, annotation, organelle, genome, chloroplast, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
Human Frontier Science Program ;
Max Planck Society ;
German Science Foundation
PMID:28486635 Free, Freely available biotools:geseq https://bio.tools/geseq SCR_017336 2026-07-27 09:35:31 375
HOMOZYGOSITYMAPPER
 
Resource Report
Resource Website
100+ mentions
HOMOZYGOSITYMAPPER (RRID:SCR_001714) HomozygosityMapper analysis service resource, service resource, data analysis service, production service resource A web-based approach of homozygosity mapping that can handle tens of thousands markers. User can upload their own SNP genotype files to the database. Intuitive graphic interface is provided to view the homozygous stretches, with the ability of zooming into single chromosomes or user-defined chromosome regions. The underlying genotypes in all samples are displayed. The software is also integrated with our candidate gene search engine, GeneDistiller, so that users can interactively determine the most promising gene. (entry from Genetic Analysis Software) gene, genetic, genomic, perl, genotype, homozygosity score, homozygosity, bio.tools, FASEB list is listed by: OMICtools
is listed by: Genetic Analysis Software
is listed by: bio.tools
is listed by: Debian
has parent organization: Charite - Universitatsmedizin Berlin; Berlin; Germany
PMID:19465395 Free, Freely Available nlx_154069, biotools:homozygositymapper, OMICS_00123 https://bio.tools/homozygositymapper SCR_001714 2026-07-27 09:31:17 121

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