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URL: http://iregulon.aertslab.org/
Proper Citation: iRegulon (RRID:SCR_028223)
Description: Software tool to reverse-engineer transcriptional regulatory networks from co-expressed gene sets by identifying master transcription factors (TFs) and their direct target genes. It operates by scanning for enriched TF binding motifs in promoter regions, utilizing over 10,000 position weight matrices (PWMs) for human, mouse, and Drosophila. Used to enable gene regulatory network mapping directly based on motif enrichment in co-expressed gene set.
Resource Type: software application, source code, software resource
Defining Citation: PMID:25058159
Keywords: reverse-engineer transcriptional regulatory networks, co-expressed gene sets, identifying master transcription factors and their direct target genes,
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