Resource Report

URL: http://swift.cmbi.ru.nl/gv/hssp/

Proper Citation: HSSP (RRID:SCR_004953)

Description: HSSP (homology-derived structures of proteins) is a derived database merging structural (2-D and 3-D) and sequence information (1-D). For each protein of known 3D structure from the Protein Data Bank, the database has a file with all sequence homologues, properly aligned to the PDB protein. Homologues are very likely to have the same 3D structure as the PDB protein to which they have been aligned. As a result, the database is not only a database of sequence aligned sequence families, but it is also a database of implied secondary and tertiary structures. Likely secondary structure are carried over from the PDB protein to each homologous protein. Tertiary structure models can be built by fitting the sequence of the homologue as aligned into the 3D template of the protein of known structure. Special software is needed to construct 3D models by homology, such WHATIF by Gert Vriend or MaxSprout by Liisa Holm and Chris Sander. The command rsync can be used to obtain a local copy of the HSSP. We appreciate receiving an Email from people who do so, but there are no strings attached. Everybody can freely download the files, academia and industry alike. If your institute''s firewall doesn''t allow you to use the (preferred) rsync way of obtaining HSSP files, feel free to work with FTP. The files are in that case available from: ftp://ftp.cmbi.ru.nl//pub/molbio/data/hssp/

Abbreviations: HSSP

Synonyms: Homology-derived Secondary Structure of Proteins, homology-derived structures of proteins, HSSP - Homology derived Secondary Structure of Proteins, HSSP database, HSSP - Homology-derived Secondary Structure of Proteins, Homology derived Secondary Structure of Proteins

Resource Type: database, data or information resource

Defining Citation: PMID:2017436

Keywords: gold standard, bio.tools