URL: http://www.yandell-lab.org/software/vaast.html
Proper Citation: VAAST (RRID:SCR_002179)
Description: A probabilistic search tool for identifying damaged genes and their disease-causing variants in personal genome sequences. VAAST combines elements of phylogenetic conservation, amino acid substitution, and aggregative approaches to variant prioritization into a single unified likelihood-framework that allows users to accurately identify damaged genes and deleterious variants. The software can score both coding (SNV, indel and splice site) and non-coding variants (SNV), evaluating the cumulative impact of both types of variants simultaneously. It can identify rare variants causing rare genetic diseases and can also use both rare and common variants to identify genes responsible for common diseases.
Abbreviations: VAAST, VAAST 2
Synonyms: Variant Annotation Analysis and Search Tool, Variant Annotation Analysis & Search Tool
Resource Type: sequence analysis software, data analysis software, data processing software, software resource, software application, standalone software
Defining Citation: PMID:23836555, PMID:21700766
Keywords: sequence analysis software, genetic, variant classifier, amino acid substitution, disease, genome interpretation, variant prioritization, disease gene prioritization, genomic variation, bio.tools
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