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Gray matter volume alterations in de novo Parkinson's disease: A mediational role in the interplay between sleep quality and anxiety.

Guixiang He | Xiaofang Huang | Haihua Sun | Yi Xing | Siyu Gu | Jingru Ren | Weiguo Liu | Ming Lu
CNS neuroscience & therapeutics | 2024

Parkinson's disease (PD) is increasingly recognized for its non-motor symptoms, among which emotional disturbances and sleep disorders frequently co-occur. The commonality of neuroanatomical underpinnings for these symptoms is not fully understood. This study is intended to investigate the differences in gray matter volume (GMV) between PD patients with anxiety (A-PD) and those without anxiety (NA-PD). Additionally, it seeks to uncover the interplay between GMV variations and the manifestations of anxiety and sleep quality.

Pubmed ID: 39031989

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Associated grants

  • Agency: The Science and Technology Program of Jiangsu Province,
    Id: BE2019611
  • Agency: National Natural Science Foundation of China,
    Id: 81903589
  • Agency: National Key Research and Development Program of China,
    Id: 2017YFC1310302

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SPSS (tool)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

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