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Effect of ultrasound-mediated blood-spinal cord barrier opening on survival and motor function in females in an amyotrophic lateral sclerosis mouse model.

Anne-Sophie Montero | Ilyes Aliouat | Matthieu Ribon | Michael Canney | Lauriane Goldwirt | Samia Mourah | Félix Berriat | Christian S Lobsiger | Pierre-François Pradat | François Salachas | Gaëlle Bruneteau | Alexandre Carpentier | Séverine Boillée
EBioMedicine | 2024

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a progressive loss of motor neurons. The limited efficacy of recent therapies in clinical development may be linked to lack of drug penetration to the affected motor neurons due to the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB).

Pubmed ID: 38996764

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Fiji (tool)

RRID:SCR_002285

Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.

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RRID:SCR_006525

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edgeR (tool)

RRID:SCR_012802

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RRID:SCR_015687

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Microsoft Excel (tool)

RRID:SCR_016137

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clusterProfiler (tool)

RRID:SCR_016884

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RRID:AB_321252

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Ki-67 Pure B56 100ug (antibody)

RRID:AB_396287

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RRID:AB_322769

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Anti Iba1, Rabbit antibody (antibody)

RRID:AB_839504

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