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An in vitro model system for testing chemical effects on microbiome-immune interactions - examples with BPX and PFAS mixtures.

Florence Fischer | Arkadiusz Pierzchalski | Sarah Riesbeck | Alix Sarah Aldehoff | Victor Alfonso Castaneda-Monsalve | Sven-Bastiaan Haange | Martin von Bergen | Ulrike Elisabeth Rolle-Kampczyk | Nico Jehmlich | Ana Claudia Zenclussen | Gunda Herberth
Frontiers in immunology | 2024

More than 350,000 chemicals make up the chemical universe that surrounds us every day. The impact of this vast array of compounds on our health is still poorly understood. Manufacturers are required to carry out toxicological studies, for example on the reproductive or nervous systems, before putting a new substance on the market. However, toxicological safety does not exclude effects resulting from chronic exposure to low doses or effects on other potentially affected organ systems. This is the case for the microbiome-immune interaction, which is not yet included in any safety studies.

Pubmed ID: 38953021

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

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Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


AppliChem (tool)

RRID:SCR_005814

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Promega (tool)

RRID:SCR_006724

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Thermo Fisher Scientific (tool)

RRID:SCR_008452

Commercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.

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BD Biosciences (tool)

RRID:SCR_013311

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